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KMID : 0380620080400060686
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Korean Journal of Food Science and Technology
2008 Volume.40 No. 6 p.686 ~ p.690
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Beneficial Effect of Curcumin on Epidermal Permeability Barrier Function in Hairless Rat
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Jeon Hee-Young
Kim Jeong-Kee
Kim Wan-Gi
Lee Sang-Jun
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Abstract
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Recent research has shown that curcumin has beneficial effects in a variety of skin diseases, includingscleroderma, psoriasis, and skin cancer. In this study, we assessed the effects of curcumin on epidermal permeability barrierfunction in vivo and in vitro. In order to evaluate the effects of curcumin on epidermal permeability barrier function invivo, hairless rats were exposed to UVB irradiation, and curcumin was administered orally at a dosage of 150mg/kg perday for 8 weeks. Transepidermal water loss (TEWL) and epidermal thickness were measured at the end of the experiment.The expression of filaggrin, a marker of keratinocyte differentiation, and serine palmitoyltransferase (SPT), a marker of theformation of the stratum corneum lipid barrier, in human HaCat keratinocytes were analyzed. The in vivo results showedthat an 8 week administration of curcumin markedly prevented the UVB-induced increase in TEWL. The UV-inducedincrease in epidermal thickness was also reduced significantly by curcumin treatment. The in vitro results demonstrated theconcentration-dependent effects of curcumin on the expression of both filaggrin and SPT in HaCat cells, reflecting thenotion that curcumin can induce epidermal keratinocyte differentiation and can improve the recovery of skin barrierfunctions. These results show that curcumin is a promising candidate for the improvement of epidermal permeabilitybarrier function.
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KEYWORD
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curcumin, epidermal permeability barrier function, filaggrin, serine palmitoyltransferase
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